LSD is one of the most potent, mood-changing chemicals. It is manufactured from lysergic acid, which is found in the ergot fungus that grows on rye and other grains.

It is produced in crystal form in laboratories, mainly in the United States. These crystals are converted to a liquid for distribution. It is odorless, colorless, and has a slightly bitter taste.

Known as “acid” and by many other names, LSD is sold on the street in small tablets (“microdots”), capsules or gelatin squares (“window panes”). It is sometimes added to absorbent paper, which is then divided into small squares decorated with designs or cartoon characters (“loony toons”). Occasionally it is sold in liquid form.

LSD users call an LSD experience a “trip,” typically lasting twelve hours or so. When things go wrong, which often happens, it is called a “bad trip,” another name for a living hell.


When ingested into the human body, LSD acts as a 5-HT (serotonin) receptor activator, while also dramatically increasing serotonin levels in the brain by deactivating systems that regulate serotonin levels.

Of the 15 different serotonin receptors in the brain, ACID mostly prefers the 2A subtype (5-HT2A). The 5-HT2A receptor is involved in cognitive processes in the prefrontal cortex.

This is an important point, for this is where many of LSD’s benefits come from: its involvement in the prefrontal cortex.

The prefrontal cortex is thought to be active in planning complex cognitive behavior, personality expression, decision-making, and moderating social behavior.

It also plays a key role in a human’s ability to process information from all other brain systems, and make goal-directed decisions as a result.

Recently, researchers at The Beckley Foundation began to investigate the specific effects of LSD on the brain.

The research is led by a group of neuroscientists at the Imperial College London.

They raised money for the research through a crowd-funded campaign.

Beckley’s latest study involved giving 20 volunteers a small dose of LSD and then using MRI and MEG imaging to show how it affects brain processes.

The researchers believe Acid may reduce blood flow to the control centers of the brain and thus dampening their activity.

It’s thought that this increase in brain connectivity, or ‘entropy’, gives rise to the creative and unique thought patterns associated with the psychedelic experience.

How is it abused?

LSD is available in saturated absorbent paper (e.g., blotter paper, divided into small, decorated squares, with each square representing one dose), tablets or “micro dots,” saturated sugar cubes, or in a liquid form. LSD is abused orally.

What is its effect on the body?

Dilated pupils, higher body temperature, increased heart rate and blood pressure, sweating, loss of appetite, sleeplessness, dry mouth, and tremors. While under the influence, the user may suffer impaired depth and time perception accompanied by: distorted perception of shape and size of objects, movements, colors, sound, touch, and the user’s own body image. The ability to make sound judgments and see common dangers is impaired, making the user susceptible to personal injury. It is possible for users to suffer acute anxiety and depression after an LSD “trip.” Hallucinogen Persisting Perception Disorder, which may include fragmentary recurrences of certain aspects of the drug experience or “flashbacks” have been reported days, and even months, after taking the last dose.

What are its overdose effects?

Longer, more intense “trip” episodes may occur with larger doses. Serious psychological harm can occur after administration, including fear, depression, anxiety, and paranoia, and can be long-lasting. Death after LSD use is rare.


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